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KMID : 1098420080160010027
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Korean Journal of Medicinal Crop Science
2008 Volume.16 No. 1 p.27 ~ p.32
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Crassirhizomae rhizoma Exhibits Anti-Allergic Activity through Inhibition of Syk Kinase in Mast Cells
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Kim Young-Mi
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Abstract
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This study aimed to investigate the anti-allergic activity and the mechanism of action of Crassirhizomae rhizoma (CR). The extract of CR exhibited potent inhibitory activity in mast cells; its values were for rat basophile leukemia (RBL)-2H3 mast cells and for bone marrow-derived mast cells by antigen stimulation. It also suppressed the expression of TNF- and IL-4 mRNAs in RBL-2H3 cells. In an in-vivo animal allergy model, it inhibited a local allergic reaction, passive cutaneous anaphylaxis (PCA), in a dose-dependent manner. With regard to the mechanism of action, CR inhibited the activating phosphorylation of Syk kinase, a key signaling protein for the activation of mast cells. Taken together, these results strongly suggested that the anti-allergic activity of CR is mediated through the inhibition of histamine release and allergic cytokine production by the inhibition of Syk in mast cells.
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KEYWORD
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Crassirhizomae rhizoma, Mast cells, Anti-Allergic Activity, Syk Kinase
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